Thermo Fisher Scientific Phospho-E2F1 (Ser337) Polyclonal Antibody
E2F1 단백질의 Ser337 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합. Protein A 및 항원 친화 크로마토그래피로 정제됨. PBS buffer에 0.09% sodium azide 포함, 4°C 또는 -20°C 보관 권장.
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- PA512585
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Applications
Western Blot (WB)
Immunohistochemistry (Paraffin) (IHC (P))
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S337 of human E2F1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979907 |
Target Information
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of the cell cycle and the action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.
E2F proteins contain several evolutionally conserved domains, including:
- DNA binding domain
- Dimerization domain (interacts with DP proteins)
- Transactivation domain (acidic amino acids enriched)
- Tumor suppressor protein association domain (embedded within transactivation domain)
E2F1, along with E2F2 and E2F3, also possesses a cyclin binding domain. It binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner and can mediate both cell proliferation and p53-dependent/independent apoptosis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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