Thermo Fisher Scientific Phospho-E2F1 (Ser337) Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500
• Publications: -

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:100
• Publications: -

Product Specifications

Target Information

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of the cell cycle and the action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.
E2F proteins contain several evolutionally conserved domains, including:

• DNA binding domain
• Dimerization domain (interacts with DP proteins)
• Transactivation domain (acidic amino acids enriched)
• Tumor suppressor protein association domain (embedded within transactivation domain)

E2F1, along with E2F2 and E2F3, also possesses a cyclin binding domain. It binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner and can mediate both cell proliferation and p53-dependent/independent apoptosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.