Thermo Fisher Scientific FIR Polyclonal Antibody
Thermo Fisher Scientific의 FIR Polyclonal Antibody는 인간 FIR 단백질을 인식하는 항-토끼 IgG 항체로, ICC/IF에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 액상 형태로 제공됩니다. 연구용으로만 사용되며 신경세포 리모델링 관련 연구에 유용합니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human FIR. Recombinant protein control fragment (Product #RP-106645) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2662261 |
Product Specific Information
Immunogen sequence:
VEESDNEWSVP HCFTIYAAQK TIVVAASTRL EKEKWMLDLN SAIQAAKSGG DTAPALPGRT VCTRPPRSPN EVSLEQESED DARGVR
Highest antigen sequence identity to the following orthologs:
- Mouse: 75%
- Rat: 75%
Target Information
FARP2 (FERM, RhoGEF and pleckstrin domain-containing protein 2), also known as PLEKHC3 or FIR (FERM domain including RhoGEF), is a 1,545 amino acid protein containing one FERM domain, one DH domain, and two PH domains.
It exists as two alternatively spliced isoforms that are abundantly expressed in brain, lung, and testis, as well as in embryonic hippocampal and cortical neurons.
FARP2 functions as a Rho-guanine nucleotide exchange factor that activates RAC1 and regulates neurite remodeling of embryonic neurons.
Sema3A binding to neuropilin-1 induces dissociation of FARP2 from plexin-A1, activating its Rac GEF activity—critical for axon repulsion and suppression of neuronal adhesion.
Downregulation of the FARP2 gene has been implicated in autism.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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