Thermo Fisher Scientific DCAF4 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MNKSRWQSRR RHGRRSHQQN PWFRLRDSED RSDSRAAQPA HDSGHGDDES PSTSSGTAGT SSVPELPGFY FDPEKKRYFR LLPGHNNCNP LTKESIRQKE MESKRLRLLQ EEDRRKKIAR

Target Information

The nuclear protein p100 is a proliferation-associated protein whose expression is restricted to cell cycle phases S, G2, and M. It is exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. During mitosis, it is strictly associated with the spindle pole and mitotic spindle, while during S and G2 phases, it is diffusely distributed throughout the nucleus. The full-length cDNA encodes a 747-amino acid protein with a putative ATP/GTP-binding site motif. RT-PCR analysis demonstrated strong expression in lung carcinoma cell lines but not in normal lung tissues. Expression was also observed in adult placenta, skeletal muscle, thymus, testis, small intestine, and in fetal brain, liver, and kidney. P100 expression is also correlated with cancer prognosis.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.