Thermo Fisher Scientific Nitrated-alpha Synuclein (Tyr125, Tyr133) Monoclonal Antibody (24.8)
파킨슨병 및 알츠하이머 연구용 니트로화 알파-시뉴클레인 단클론 항체. Western blot, IHC 등 다양한 응용 가능. Mouse IgG1, kappa 형식으로 제공되며, 1 mg/mL 농도의 액상 형태. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,500 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200–1:500 |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-Dependent |
| Immunocytochemistry (ICC/IF) | Assay-Dependent |
| Flow Cytometry (Flow) | 1 µg/1×10⁶ cells |
Product Specifications
| Specification | Detail |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 24.8 |
| Immunogen | Nitrated alpha-synuclein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11151957 |
Product Specific Information
Suggested positive control: whole Alzheimer’s Disease brain lysate.
Target Information
Alpha-synuclein is a member of the synuclein family, including beta- and gamma-synuclein. These proteins are abundant in the brain and play roles in synaptic transmission and membrane trafficking.
Alpha- and beta-synuclein selectively inhibit phospholipase D2, implicating them in signaling pathways.
Mutations in the SNCA gene, encoding alpha-synuclein, are linked to Parkinson’s disease pathogenesis. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in Alzheimer’s disease brains.
Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Diseases associated with SNCA include Parkinson Disease 1 (Autosomal Dominant) and Dementia with Lewy Bodies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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