Thermo Fisher Scientific CD26 Polyclonal Antibody

Thermo Fisher Scientific CD26 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive test controls: 293T, Mouse lung, Mouse liver, Rat lung, Rat kidney
• Localization: Apical cell membrane, Cell junction, Cell membrane, Cell projection, Membrane raft, Secreted, Single-pass type II membrane protein, invadopodium membrane, lamellipodium membrane

Immunogen sequence:
NKGTDDATAD SRKTYTLTDY LKNTYRLKLY SLRWISDHEY LYKQENNILV FNAEYGNSSV FLENSTFDEF GHSINDYSIS PDGQFILLEY NYVKQWRHSY TASYDIYDLN KRQLITEERI PNNTQWVTWS PVGHKLAYVW NNDIYVKIEP NLPSYRITWT GKEDIIYNGI TDWVYEEEVF SAYSALWWSP NGTFLAYAQF NDTEVPLIEY SFYSDESLQY PKTVRVPYPK AGAVNPTVKF FVVNTDSLSS VTNATSIQIT APASMLIGDH YLCDVTWATQ ERISLQWLRR IQNYSVMDIC DYDESSGRWN CLVARQHIEM STTGWVGRFR PSEPHFTLDG NSFYKIISNE EGYRHICYFQ IDKKDCTFIT KGTWEVIGIE ALTSDYLYYI SNEYKGMPGG RNLYKIQLSD YTKVTCLSCE LNPERCQYYS VSFSKEAKYY QLRCSGPGLP LYTLHSSVND KGLRVLEDNS ALDKMLQNVQ MPSKKLDFII LNETKFWYQM ILPPHFDKSK KYPLLLDVYA GPCSQKADTV FRLNWATYLA STENIIVASF DGRGSGYQGD KIMHAINRRL GTFEVEDQIE AARQFSKMGF VDNKRIAIWG WSYGGYVTSM VLGSGSGVFK CGIAVAPVSR WEYYDSVYTE RYMGLPTPED NLDHYRNSTV MSRAENFKQV EYLLIHGTAD DNVHFQQSAQ ISKALVDVGV DFQAMWYTDE DHGIASSTAH QHIYTHMSHF IKQCFSLP

Target Information

CD26 (dipeptidyl peptidase IV, DPP IV, adenosine deaminase binding protein) is a homodimeric atypical serine protease belonging to the prolyl oligopeptidase family. It is expressed on lymphocytes and upregulated during T-cell activation, also found on activated B cells, NK cells, and epithelial tissues.
CD26 is involved in T-cell activation, cell adhesion with extracellular matrix proteins (fibronectin, collagens), and HIV infection. It functions as a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides.
Alterations in CD26 activity correlate with malignant transformation and tumor grade. It is expressed in various blood cells and fibroblast-related cells, with changes observed in monocytes and CD4+ T cells during rheumatoid arthritis and systemic lupus erythematosus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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