Thermo Fisher Scientific MMP2 Monoclonal Antibody (VB3)
Human MMP2 단백질을 타겟으로 하는 VB3 클론의 Mouse monoclonal antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용 가능. Protein G 정제, PBS 버퍼에 0.2% BSA 포함. 연구용으로 인체 시료에서 높은 특이성 및 재현성 제공.
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Thermo Fisher Scientific MMP2 Monoclonal Antibody (VB3)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 14 publications |
| Immunohistochemistry (IHC) | – | View 23 publications |
| Immunocytochemistry (ICC/IF) | Assay-dependent | View publications |
| Immunoprecipitation (IP) | 2 µg/mL | View publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | VB3 |
| Immunogen | Human native 72kDa MMP-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982241 |
Additional Formats
Product Specific Information
MA5-14186 antibody targets MMP-2 (72kDa Collagenase IV) in IF, IP, and WB applications, showing reactivity with human samples.
The immunogen used is human native 72kDa MMP-2.
Target Information
Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a conserved metal-binding active site and are inhibited by tissue inhibitors of metalloproteinases (TIMPs). MMPs and TIMPs regulate angiogenesis.
MMP2 is synthesized as a 631 amino acid proenzyme activated by cleavage of the first 80 amino acids. It includes propeptide, catalytic, and hemopexin domains. MMP2 participates in tissue remodeling and mutations in its gene are linked to Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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