Thermo Fisher Scientific ABCA1 Monoclonal Antibody (AB1.G6)
ABCA1 단백질을 검출하는 Mouse IgG1 모노클로날 항체로, WB, IHC(F), ELISA, IP에 사용 가능. 인간 시료에서 ABCA1 인식. Tangier 질환 관련 연구 및 HDL 콜레스테롤 대사 연구용. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| ELISA | 3–6 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | AB1.G6 |
| Immunogen | Amino acids 1800–2260 of ABCA1 (UniProt ID: O95477-1, Human) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2220135 |
Product Specific Information
MA1-91401 detects ABCA1 from human samples.
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) are associated with Tangier disease (TD), an autosomal recessive disorder characterized by absence of plasma HDL, cholesterol ester deposits in the reticuloendothelial system, and altered cellular lipid trafficking.
ABCA1 mediates the apo-A1–associated export of cholesterol and phospholipids from cells. It is expressed on the plasma membrane and Golgi complex, and its expression is regulated by cholesterol flux.
Regulation of cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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