Thermo Fisher Scientific ME2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human ME2 protein. Suitable for WB, IHC(P), and ICC/IF applications. Detects endogenous ME2 levels. Affinity-purified and supplied as liquid form in PBS with glycerol. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ME2 (Accession P23368), corresponding to amino acid residues P200–T250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2900197 |
Product Specific Information
Antibody detects endogenous levels of total ME2.
Target Information
ME2 encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein that catalyzes the oxidative decarboxylation of malate to pyruvate. It was previously weakly linked to Friedreich ataxia, which has since been attributed to a different gene. Certain single-nucleotide polymorphism haplotypes of ME2 are associated with increased risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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