Thermo Fisher Scientific ADAMTS4 Monoclonal Antibody (OTI6F8)
ADAMTS4 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(P)에서 검증됨. 인간 시료 반응성. 액상 형태로 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보관. 단백질 분해 관련 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6F8 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 296–577 of ADAMTS4 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2723842 |
Target Information
This gene encodes a member of the ADAMTS protein family. Members of this family share distinct protein modules, including:
- A propeptide region
- A metalloproteinase domain
- A disintegrin-like domain
- A thrombospondin type 1 motif
Individual members differ in the number of C-terminal TS motifs and may have unique C-terminal domains.
The enzyme encoded by this gene lacks a C-terminal TS motif and is responsible for the degradation of aggrecan (a major cartilage proteoglycan) and brevican (a brain-specific extracellular matrix protein).
These cleavage activities suggest key roles in arthritic disease and central nervous system functions, potentially involved in glioma progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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