Thermo Fisher Scientific Human TMP21 Synthetic Peptide
인간 TMP21 단백질의 중심부 18개 아미노산 서열 기반 합성 펩타이드로, 항체 차단용으로 사용 가능. 순도 높은 액상 형태이며 PBS/BSA 완충액에 보관. 연구용으로 γ-시크리타제 활성 조절 관련 실험에 적합.
- 카탈로그번호
- PEP0436
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Human TMP21 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the center of human TMP21.
PEP-0436 can be used as a blocking peptide with polyclonal antibody PA5-20316.
Target Information
TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates γ-secretase but not ε-secretase cleavage activity of the amyloid precursor protein.
The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1. Together, these proteins cleave the amyloid precursor protein at γ- and ε-sites, leading to accumulation of the Abeta cleavage product associated with Alzheimer’s disease.
Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21, indicating its regulatory role in the complex. Suppression of TMP21 expression by siRNA in transfected cells increased γ-secretase activity and Abeta production, demonstrating that TMP21 modulates γ-secretase activity.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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