Thermo Fisher Scientific Human TMP21 Synthetic Peptide

Thermo Fisher Scientific Human TMP21 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the center of human TMP21.
PEP-0436 can be used as a blocking peptide with polyclonal antibody PA5-20316.

Target Information

TMP21 is a ubiquitously expressed protein involved in vesicular targeting and protein transport. It is also a component of the presenilin complex and modulates γ-secretase but not ε-secretase cleavage activity of the amyloid precursor protein.

The presenilin complex includes APH1, nicastrin, PEN2, and presenilin-1. Together, these proteins cleave the amyloid precursor protein at γ- and ε-sites, leading to accumulation of the Abeta cleavage product associated with Alzheimer’s disease.

Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21, indicating its regulatory role in the complex. Suppression of TMP21 expression by siRNA in transfected cells increased γ-secretase activity and Abeta production, demonstrating that TMP21 modulates γ-secretase activity.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.