Thermo Fisher Scientific Human TSLP Synthetic Peptide

Thermo Fisher Scientific Human TSLP Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the carboxy terminus of human TSLP.
PEP-0439 can be used as a blocking peptide with polyclonal antibody PA5-20319.

Target Information

TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain.
It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c(+) dendritic cells, naive CD4(+), and CD8(+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation.
TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4(+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis.
It is expressed in heart, liver, and prostate.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.