Thermo Fisher Scientific Diazepam Binding Inhibitor (DBI) Monoclonal Antibody (OTI6E12)

Applications

• Western Blot (WB): Tested dilution 1:500

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended product: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

The Diazepam Binding Inhibitor (DBI) gene encodes a protein regulated by hormones and involved in lipid metabolism. It displaces beta-carbolines and benzodiazepines that modulate signal transduction at type A GABA receptors in brain synapses.
This protein is conserved from yeast to mammals, with a highly conserved hydrophobic binding domain for medium- and long-chain acyl-CoA esters.
DBI mediates feedback regulation of pancreatic secretion and postprandial release of cholecystokinin, and plays a role in corticotropin-dependent adrenal steroidogenesis.
Three pseudogenes have been identified on chromosomes 6, 8, and 16. Multiple transcript variants encoding different isoforms have been described.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.