Thermo Fisher Scientific PANK2 Monoclonal Antibody (OTI4B3), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Pantothenate kinase is an essential regulatory enzyme in CoA biosynthesis, catalyzing cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine.
CoA acts as a major acyl carrier, playing a central role in intermediary and fatty acid metabolism.
Mutations in PANK2 are linked to pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS).
PKAN is an autosomal recessive neurodegenerative disorder associated with iron accumulation in the brain.
Mutations in PANK2 also cause hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.