Thermo Fisher Scientific ROS1 Monoclonal Antibody (OTI5D2), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases transfer phosphate groups from ATP to substrate proteins, mediating signal transduction in eukaryotic cells. These enzymes regulate metabolism, transcription, cell cycle progression, cytoskeletal organization, apoptosis, and differentiation.
The protein kinase family includes over 500 genes, divided into eight major groups based on catalytic domain sequences. The tyrosine kinase (TK) group primarily regulates cell-cell interactions such as differentiation, adhesion, motility, and apoptosis. Approximately 90 TK genes have been sequenced, including receptor TKs (EGFR, EPH, FGFR, PDGFR, TRK, VEGFR) and cytosolic TKs (ABL, FAK, JAK, SRC).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.