Thermo Fisher Scientific Langerin/CD207 (Marker of Langerhans Cells) Recombinant Rabbit Monoclonal Antibody (LGRN/3136R)

Applications

Tested Dilution

Publications

ELISA (ELISA)

2-4 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

LGRN/3136R

Immunogen

Recombinant fragment (around aa74-213) of human Langerin protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Langerin (CD207),uniProtId:Q9UJ71-1,ncbiNodeId:9606,antigenRange:74-213,antigenLength:328,antigenImageFileName:50489-RBM2-P1ABX_Langerin_CD207_Q9UJ71-1_Rabbit.svg,antigenImageFileNamePDP:50489-RBM2-P1ABX_Langerin_CD207_Q9UJ71-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Target Information

Langerin (CD207) is a type II membrane-associated C-type lectin known to be expressed exclusively by Langerhans cells. Lamgerin recognizes mannose residues via its single carbohydrate recognition domain (CRD). Langerin is localized not only on the cell surface, but also intracellularly in close association with Birbeck granules. Transfection of Langerin cDNA into fibroblasts creates a compact network of membrane structures with typical features of Birbeck granules (BG). Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.