Thermo Fisher Scientific GM-CSF Monoclonal Antibody (3D3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-15614 targets CSF2 in indirect ELISA and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of human CSF2 (aa18–144) expressed in E. coli.
MA5-15614 detects CSF2, which has a predicted molecular weight of approximately 16 kDa.

Target Information

The GM-CSF gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes.
The active form exists as a homodimer in the extracellular space.
This gene is located in a cluster at chromosome region 5q31, associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia.
Other genes in the cluster include interleukins 4, 5, and 13.
The gene promotes tissue inflammation, and elevated cytokine levels have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome.
Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.