Thermo Fisher Scientific RAB11A Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1-2 µg/mL

View 24 publications 24 publications

Immunohistochemistry (IHC)

-

View 8 publications 8 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:100

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1-5 µg

View 57 publications 57 publications

ELISA (ELISA)

0.1-1 µg/mL

-

Immunoprecipitation (IP)

5 µg

-

Immunomicroscopy (IM)

Assay-dependent

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

-

View 2 publications 2 publications

Product Specifications

Species Reactivity

Dog, Human, Mouse, Non-human primate, Rabbit, Rat

Published species

Bacteria, Dog, Hamster, Human, Mouse, Non-human primate, Rat, Rhesus monkey

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide derived from the C-terminal hypervariable region of the human Rab11a sequence. This peptide shares 10 of 17 residues with the related Rab11b protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RAB11A,uniProtId:P62491-1,ncbiNodeId:9606,antigenRange:216,antigenLength:216,antigenImageFileName:71-5300_RAB11A_P62491-1_Rabbit.svg,antigenImageFileNamePDP:71-5300_RAB11A_P62491-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

0.1% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2533987

Product Specific Information

This polyclonal antibody reacts specifically with the human Rab11A protein. Cross-reactivity with other Rab family members has not been detected.

Positive control: Human HEK-293 cells

Target Information

Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.