Thermo Fisher Scientific Pan-cadherin Polyclonal Antibody
다중 종에서 반응하는 Rabbit 폴리클로날 Pan-cadherin 항체로, N-, E-, P-, R-cadherin을 포함한 카드헤린 패밀리 전체를 검출 가능. Western blot, IHC, ICC 등 다양한 응용에 사용. 세포 간 접착 및 adherens junction 연구에 유용.
- 카탈로그번호
- 717100
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 9 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2–3 µg/mL | View 2 publications |
| ELISA | Assay-dependent | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Chicken, Human, Mouse, Non-human primate, Rat, Xenopus |
| Published Species | Bovine, Dog, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide derived from the carboxy-terminus of the chicken N-cadherin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533992 |
Product Specific Information
This peptide antibody is broadly cross-reactive with all members of the cadherin family of proteins including N-cadherin, E-cadherin, P-cadherin, and R-cadherin. It exhibits broad species cross-reactivity across human, bovine, mouse, rat, chicken, amphibian, and other species.
Rabbit anti-pan-Cadherin serves as a ubiquitous cadherin probe and a marker for adherens junctions.
Product 71-7100 was successfully used in immunofluorescence analysis of pan-cadherin in MDCK cells.
Target Information
Pan Cadherin (including CDH1, CDH2, CDH3, CDH4) belongs to a family of transmembrane molecules mediating calcium-dependent intercellular adhesion.
Cadherins regulate morphogenetic movements during development and control cell surface adhesion through homotypic interactions.
N-cadherin function depends on association with the actin-cytoskeleton and interactions between its C-terminal region and cytoplasmic catenin proteins.
This gene encodes a classical cadherin from the cadherin superfamily, a calcium-dependent cell-cell adhesion glycoprotein with five extracellular cadherin repeats, a transmembrane domain, and a conserved cytoplasmic tail.
It plays roles during gastrulation and in establishing left-right asymmetry, and contributes to synaptic adhesion in the central nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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