Thermo Fisher Scientific RNF3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.125 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: FYHKLGMEVP GDIKGETCSA KQHLDSHRNG ETKADDSSNK EAAEEKPEED
• Short-term storage: 2–8°C (up to 1 week)
• Long-term storage: -20°C in small aliquots to prevent freeze-thaw cycles

Predicted Homology:

• Cow: 93%
• Dog: 93%
• Guinea Pig: 86%
• Horse: 100%
• Human: 100%
• Mouse: 86%
• Pig: 100%
• Rabbit: 86%
• Rat: 86%

Target Information

Phosphorylase kinase is a hexadecameric enzyme composed of four copies of four subunits encoded by separate genes: PHKA, PHKB, PHKG, and PH kDa.
This serine/threonine-specific kinase converts glycogen phosphorylase b to glycogen phosphorylase a, releasing glucose-1-phosphate from glycogen.

PHKB (Phosphorylase b kinase regulatory subunit beta) is a 1093 amino acid subunit with regulatory functions controlled by phosphorylation.
Defects in the PHKB gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle.
This disease is characterized by mild hepatomegaly, slightly elevated transaminase and plasma lipids, no clinical muscle involvement, and gradual improvement with age.
Four isoforms of PHKB are produced through alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.