Thermo Fisher Scientific RAR gamma-1 Polyclonal Antibody

Applications

• Western Blot (WB): 1.0 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  YPGAGFPFAF PGALRGSPPF EMLSPSFRGL GQPDLPKEMA SLSVETQSTS
• Storage guidance:
  For short term use, store at 2–8°C up to 1 week.
  For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Predicted homology:
  Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rat: 100%; Sheep: 100%

Target Information

Retinoic acid, a metabolite of vitamin A, is essential for normal organogenesis but acts as a teratogen at high levels during embryonic and fetal development. It functions via the nuclear protein retinoic acid receptor (RAR), part of the steroid and thyroid hormone receptor superfamily that regulates gene expression by binding specific DNA response elements.
RAR has three subtypes: alpha, beta, and gamma. Two main isoforms of RAR gamma exist:

• RAR gamma-1: predominantly expressed in skin
• RAR gamma-2: expressed early in embryogenesis and embryonal carcinoma cells

RAR gamma is also known as RARD, and the corresponding gene for RAR gamma-1 is NR1B3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.