Thermo Fisher Scientific MNK1 Polyclonal Antibody
MNK1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA에 사용 가능. Human, Mouse, Rat 반응성. Affinity 정제, PBS/glycerol buffer, -20°C 보관. 세포질 및 핵에서 발현되는 MNK1 검출에 적합.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 374–465 of human MKNK1 (NP_003675.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.829 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914209 |
Product Specific Information
- Positive test controls: HeLa, 293T, HepG2, Mouse pancreas, Rat skeletal muscle
- Subcellular localization: Cytoplasm, Nucleus
- Immunogen sequence:
VQGQAPEKGL PTPQVLQRNS STMDLTLFAA EAIALNRQLS QHEENELAEE PEALADGLCS MKLSPPCKSR LARRRALAQA GRGEDRSPPT AL
Target Information
The MAP kinase-interacting kinases (MKNK1 and MKNK2) are activated by MAP kinases and regulate protein synthesis by phosphorylating eIF4E on Ser209, potentially contributing to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, acting as an eIF-4E kinase in vivo. Mnk2 may play a role in responses to environmental stress and cytokines. Expression of active MNK1 and MNK2 mutants reduces cap-dependent translation relative to cap-independent translation. Human Mnk2 is approximately 94% identical to murine Mnk2 and 71% identical to human Mnk1. In vitro studies show Mnk2 is a better substrate than Mnk1 for Erk2, p38MAPKα, and p38MAPKβ.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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