Thermo Fisher Scientific OX40L Monoclonal Antibody (362CT19.3.3)
OX40L (CD252)을 인식하는 Mouse IgM 단클론 항체로, Western blot에 적합합니다. 인간 시료에 반응하며 비결합형(Liquid) 형태로 제공됩니다. 단기 4°C, 장기 -20°C 보관 권장. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:4,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgM |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 362CT19.3.3 |
| Immunogen | KLH conjugated synthetic peptide between 97–125 amino acids from human TNFSF4 (OX40L, CD252, UniProt ID: P23510-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2897473 |
Target Information
The tumor necrosis factor superfamily member TNFSF4 (OX40L/CD252) is a type II membrane-bound, non-covalently linked homotrimeric protein. It is expressed on antigen-presenting cells such as dendritic cells and activated B-cells, as well as on vascular endothelial cells, mast cells, and natural killer cells.
TNFSF4 signals through the TNFRSF4 receptor, which is expressed predominantly on CD4+ T cells and certain activated CD8+ T cells.
The TNFRSF4/TNFSF4 interaction functions as a costimulatory signal required for effective communication between antigen-presenting cells and T cells, enhancing proliferation, survival, and the expression of cytokines such as RANTES, IL-2, IL-3, and IFN-γ.
This pathway plays an important role in maintaining immunotolerance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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