Thermo Fisher Scientific NRG1 Recombinant Rabbit Monoclonal Antibody (005)
Human NRG1 단백질(Ser20-Lys241)을 면역원으로 제작된 재조합 토끼 단클론 항체. ELISA에 1:5,000–1:10,000 희석으로 사용 가능. 보존제 무첨가, Protein A 정제, 1 mg/mL 농도. Human NRG1에 높은 특이성과 재현성을 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 005 |
| Immunogen | Recombinant Human NRG1 Protein (Ser20–Lys241) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786406 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone antibody DNA sequences from immunoreactive rabbits, followed by screening to select the best clones for production.
Advantages:
- High specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to rabbit immune repertoire
This antibody specifically recognizes Human NRG1.
Target Information
Neuregulin 1 (NRG1) is a 44-kDa glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase, increasing its phosphorylation on tyrosine residues.
Multiple isoforms of NRG1 are generated by alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF). These isoforms are tissue-specific and differ structurally.
- HRG isoforms: contain Ig and EGF-like domains
- GGF/GGF2 isoforms: contain kringle-like, Ig, and EGF-like domains
- SMDF isoform: contains only the EGF-like domain
All NRG1 isoforms bind to ERBB family receptors, inducing growth and differentiation in epithelial, neuronal, glial, and other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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