Thermo Fisher Scientific PERP Polyclonal Antibody
Human PERP 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용 가능. 0.5 mg/mL 농도의 액상 제품이며, PBS + 2% sucrose buffer에 보관. p53 관련 세포사멸 연구에 적합.
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Thermo Fisher Scientific PERP Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1.0 µg/mL |
| Immunohistochemistry (IHC) | 1:100 |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the middle region of human PERP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2688582 |
Product Specific Information
This target displays homology in the following species:
Cow: 86% | Dog: 86% | Guinea Pig: 86% | Horse: 93% | Human: 100% | Mouse: 86% | Rabbit: 86% | Rat: 86%
Target Information
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in the p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP, and PERP, have been identified.
PERP (also known as PIGPC1 and THW) is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates the PERP gene. The translated PERP protein mediates p53-induced apoptosis, and its expression leads to cell death.
PERP is a mediator of p53-induced apoptosis and shares sequence similarity with PMP-22/gas3, belonging to the PMP-22/gas3 family.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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