Thermo Fisher Scientific PLCG2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PLCG2 (residues 500–550). Validated for Western blot and immunoprecipitation. Supplied as unconjugated liquid at 1 mg/mL concentration. For research use only.
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- A305891Ax (2개 옵션)
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Applications
Western Blot (WB)
- Tested Dilution: 1:10,000–1:25,000
Immunoprecipitation (IP)
- Tested Dilution: 50–100 µL/mg of lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A region between residue 500 and 550 of human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Target Information
Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in receptor-mediated signal transduction through the generation of two second messengers, inositol 1,4,5-triphosphate and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate.
There are multiple mammalian PLC isozymes, including PLC beta1, beta2, beta3, beta4, gamma1, gamma2, delta1, delta2, and PLCe.
PLC delta exists as four isoforms. PLC delta1, a calcium signal amplifier, is activated by an atypical GTP-binding protein and acts as an effector in oxytocin receptor and alpha1B-adrenoreceptor signaling. Mouse PLC delta1 is highly expressed in brain, heart, lung, and testis.
PLC delta is abnormally accumulated in Alzheimer’s disease brains, suggesting a role in AD pathology. PLC delta2 is markedly expressed in type II intestinal metaplasia and adenocarcinoma, and its expression may serve as a marker for gastric malignant transformation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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