Thermo Fisher Scientific CD85j (ILT2) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive Samples: Jurkat, Raji, A-431
• Cellular Location: Membrane, Single-pass type I membrane protein
• Immunogen sequence:
  GWMQTFLLTK EGAADDPWRL RSTYQSQKYQ AEFPMGPVTS AHAGTYRCYG SQSSKPYLLT HPSDPLELVV SGPSGGPSSP TTGPTSTSGP EDQPLTPTGS DPQSGLGRHL G

Target Information

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, located in the chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors, which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs).
The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It helps control inflammatory responses and cytotoxicity to focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been identified for this gene.

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For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.