Thermo Fisher Scientific MMP13 Monoclonal Antibody (VIIIA2)

Applications

Tested Dilution

Publications

Western Blot (WB)

2-4 µg/mL

View 6 publications 6 publications

Immunohistochemistry (IHC)

-

View 39 publications 39 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:12.5-1:25

View 4 publications 4 publications

Immunocytochemistry (ICC/IF)

-

View 3 publications 3 publications

Immunoprecipitation (IP)

1:25-1:50

-

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Rabbit, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

VIIIA2

Immunogen

Human recombinant collagenase-3 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Protein G

Storage buffer

PBS, pH 7.4, with 0.2% BSA

Contains

0.09% sodium azide

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10981616

Product Specific Information

MA5-14238 targets MMP-13 (Collagenase-3) in IHC (P) and IP applications and shows reactivity with Human, mouse, and Rabbit samples.

The MA5-14238 immunogen is human recombinant collagenase-3 protein.

Target Information

MMP13 (collagense 3) plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC, and ACAN. MMP13 cleaves tripal helical collagens, including type I, II, and III collagen - but has the highest activity with soluble type II collagen. It can degrade collagen type IV, XIV, and X. MMP13 plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization, and ossification. It is required for normal embryonic bone development and ossificaiton. Mutations affecting the gene can lead to spondyloepimetaphyseal dysplasia Missouri type, metaphyseal anadysplasia 1, and metaphyseal dysplasia Sphar type.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.