Thermo Fisher Scientific RAB3GAP1 Polyclonal Antibody
RAB3GAP1 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 인간 및 생쥐 시료에 반응하며, 액상 형태로 1 mg/mL 농도. 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RAB3GAP1 (Accession Q15042), corresponding to amino acid residues S537–E587 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851235 |
Product Specific Information
This antibody detects endogenous levels of total RAB3GAP1.
Target Information
RAB3GAP1 is a 981 amino acid protein belonging to the Rab3-GAP catalytic subunit family. Rab3 GAP p130 converts active RAB3-GTP to the inactive RAB3-GDP form and is essential for normal eye and brain development. Defects in Rab3 GAP p130 cause Warburg micro syndrome 1 (WARBM1), a severe autosomal recessive disorder characterized by developmental abnormalities of the eye and central nervous system, as well as microgenitalia. The Rab3 GAP p130 protein may participate in neurodevelopmental processes such as proliferation, migration, and differentiation before synapse formation, and in non-synaptic vesicular release of neurotransmitters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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