Thermo Fisher Scientific STIM2 Polyclonal Antibody
STIM2 단백질을 인식하는 Thermo Fisher의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 1 mg/mL 농도의 액상 형태. 인간, 마우스, 랫트에 반응하며, 4°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–1 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 2.5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 20 µg/mL | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the carboxy terminus of human STIM2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153417 |
Product Specific Information
- A suggested positive control is A-20 cell lysate.
- PA5-20372 can be used with blocking peptide PEP-0489.
Target Information
In T lymphocytes, Ca²⁺ entry following antigen-receptor binding occurs through store-operated Ca²⁺-release-activated Ca²⁺ (CRAC) channels. These channels consist of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), which acts as a Ca²⁺ sensor and activates the CRAC channels by migrating from endoplasmic reticulum-like sites to the plasma membrane.
STIM2, a related molecule, inhibits STIM1-mediated store-operated Ca²⁺ entry and can form complexes with STIM1, suggesting a coordinated role in controlling Ca²⁺ entry. At least three isoforms of STIM2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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