Thermo Fisher Scientific PHD3 Polyclonal Antibody
PHD3 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human 및 Mouse 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 내 산소 감지 및 HIF 관련 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 50 and 100 of human Prolyl Hydroxylase Domain-Containing Protein 3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/Tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins.
Hydroxylates specific prolines in the oxygen-dependent degradation domains (NODD and CODD) of HIF1A and HIF2A, targeting them for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
Under hypoxic conditions, hydroxylation is reduced, allowing HIFs to translocate to the nucleus and activate hypoxia-inducible genes.
EGLN3 (PHD3) plays a key role in limiting physiological activation of HIFs, regulating apoptosis in cardiomyocytes and neurons, and participating in DNA damage response via TELO2 hydroxylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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