Thermo Fisher Scientific Phospho-Lck (Tyr505) Recombinant Rabbit Monoclonal Antibody (LckY505-A3), PE

Applications

• Flow Cytometry (Flow): 5 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• Request custom conjugation

Target Information

LCK is a member of the Src-family tyrosine kinases essential for T-cell receptor (TCR) signaling. Upon TCR activation, LCK phosphorylates ITAM motifs in the zeta subunits, creating binding sites for SH2 domains of ZAP70, which is subsequently phosphorylated and activated. LCK also contributes to LAT adaptor phosphorylation, forming downstream signaling platforms. It is mainly localized to the plasma membrane, with a fraction at the Golgi apparatus potentially involved in Raf activation under weak stimulation. LCK contains N-terminal myristylation and palmitylation sites, a PTK domain, and SH2/SH3 domains mediating protein-protein interactions. It also regulates apoptosis induced by various stimuli. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternative splice variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지