Thermo Fisher Scientific DCAF12 Polyclonal Antibody
Rabbit polyclonal antibody against human DCAF12 (TCC52) for research use. Recognizes a recombinant human antigen with high identity to mouse and rat orthologs. Supplied unconjugated in liquid form, 0.2 mg/mL concentration, stored at 4°C or -20°C. Ideal...
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Thermo Fisher Scientific DCAF12 Polyclonal Antibody
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TCC52 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663562 |
Product Specific Information
Immunogen sequence:
AGSDAQGPQFG WDHSLHKRKR LPPVKRSLVY YLKNREVRLQ NETSYSRVLH GYAAQQLPSL LKEREFHLGT L
Highest antigen sequence identity to the following orthologs:
- Mouse: 99%
- Rat: 99%
Target Information
Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly expressed in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors.
One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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