Thermo Fisher Scientific HOXB7 Polyclonal Antibody, MaxPab

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MSSLYYANAL FSKYPASSSV FATGAFPEQT SCAFASNPQR PGYGAGSGAS FAASMQGLYP GGGGMAGQSA AGVYAAGYGL EPSSFNMHCA PFEQNLSGVC PGDSAKAAGA KEQRDSDLAA ESNFRIYPWM RSSGTDRKRG RQTYTRYQTL ELEKEFHYNR YLTRRRRIEI AHTLCLTERQ IKIWFQNRRM KWKKENKTAG PGTTGQDRAE AEEEEEE

Target Information

The homeobox genes encode transcription factors that regulate developmental processes such as body patterning and organogenesis. The mammalian HOX gene complex consists of 39 genes located on 4 linkage groups (clusters) across 4 chromosomes (HOXA, HOXB, HOXC, and HOXD).
HOXB7 is expressed in most malignant T-cell lines and CD4-positive peripheral blood cells, and is constitutively expressed in melanoma primary lesions and cell lines.
HOXB7 binds to and transactivates bFGF in melanoma cell lines, but SkBr3 breast adenocarcinoma is negative for both HOXB7 and bFGF expression.
HOXB7 may be a key activator of tumor-associated neoangiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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