Thermo Fisher Scientific TIP60 Monoclonal Antibody (4B3B4)
TIP60 단백질을 인식하는 Mouse monoclonal antibody(4B3B4)로, Western blot 및 ELISA에 적합합니다. Human 시료에 반응하며, Protein G 정제 방식으로 제조되었습니다. PBS buffer에 0.05% sodium azide를 포함하며, 4°C 단기 보관 및 -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4B3B4 |
| Immunogen | Purified recombinant fragment of human TIP60 (AA: 18–208) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091028 |
Target Information
TIP60 is a transcription factor originally isolated as an HIV-1 TAT-interactive protein. It interacts with the viral TAT protein, leading to HTATIP polyubiquitination and degradation. Belonging to the MYST family of histone acetyltransferases (HATs), TIP60 serves as a catalytic subunit of the NuA4 histone acetyltransferase complex, which acetylates nucleosomal histones H4 and H2A to activate transcription of select genes. As a co-regulator of transcription factors, TIP60 can either promote or suppress tumorigenesis. It also plays key roles in DNA repair, apoptosis, and signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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