Thermo Fisher Scientific MLH3 Polyclonal Antibody
MLH3 단백질을 인식하는 Thermo Fisher Scientific의 고품질 rabbit polyclonal antibody입니다. Western blot 및 IHC(Paraffin) 실험에 적합하며, 인간, 마우스, 랫트 반응성을 가집니다. 항원 친화 크로마토그래피로 정제되어 높은 순도를 제공합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 513–563 of Human MLH3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2 |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2719073 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are involved in maintaining genomic integrity during DNA replication and meiotic recombination. The MLH3 protein functions as a heterodimer with other family members. Somatic mutations in this gene are frequently found in tumors exhibiting microsatellite instability, and germline mutations are associated with hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, though only two full-length variants have been characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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