Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), Alexa Fluor 488, eBioscience
인간 IL-17A에 특이적인 중화용 모노클로날 항체로, Alexa Fluor 488 형광 표지. Flow cytometry, ELISA, ELISPOT 및 intracellular staining에 최적화됨. 염증성 사이토카인 연구 및 Th17 세포 분석에 활용 가능. 4°C 암조건 보관, 동결 금지.
- 카탈로그번호
- 53-7179-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), Alexa Fluor 488, eBioscience
Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), Alexa Fluor 488
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | - | 3 publications |
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test | 41 publications |
| ELISA | - | 4 publications |
| Neutralization | - | 1 publication |
| Radioimmune Assays (RIA) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Hamster, Human, Non-human primate, Rhesus monkey |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 488 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio64DEC17 |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10548033 |
Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 563
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 605
- Brilliant Violet 786
- eFluor 450
- eFluor 506
- eFluor 660
- FITC
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Custom conjugation available
Product Specific Information
The eBio64DEC17 antibody reacts with human IL-17A and is a neutralizing antibody.
IL-17A is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in conditions such as rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
Human IL-17A exists as glycosylated 20–30 kD homodimers produced by activated CD4+ T cells. It enhances ICAM-1 expression in fibroblasts and stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2.
In the presence of IL-17A, fibroblasts can sustain CD34+ hematopoietic progenitors and induce neutrophil maturation.
IL-23-dependent, IL-17A-producing Th17 cells are a unique subset distinct from Th1/Th2 pathways. IFN-γ and IL-4 negatively regulate Th17 generation.
Intracellular staining by eBio64DEC17 identifies the same cell population as eBio64CAP17.
Applications Reported: Detection antibody in ELISA and ELISPOT, neutralization, and intracellular staining.
Applications Tested: Pre-titrated for intracellular staining and flow cytometry at 5 µL (0.25 µg) per test (100 µL final volume).
Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a 32 kDa disulfide-linked homodimer of 136 amino acids, part of the IL-17 family (IL-17A–F).
It signals through IL-17R and regulates NF-κB and MAPK pathways, stimulating IL-6 and COX-2 expression and nitric oxide production.
IL-17A promotes inflammation and cell recruitment in autoimmune and chronic inflammatory diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.