Thermo Fisher Scientific CDKL2 Monoclonal Antibody (OTI5D9), TrueMAB
CDKL2 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P)에서 검증됨. Human 시료에 반응하며, 1 mg/mL 농도의 액상 형태로 제공. Affinity chromatography로 정제되어 높은 특이성과 재현성을 보장. 연구용으로만 사용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5D9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 291–493 of human CDKL2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The activation of signal transduction pathways by growth factors, hormones, and neurotransmitters is mediated by the MAP kinases ERK1 and ERK2. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites within a characteristic Thr-Glu-Tyr motif.
The protein kinase p56 KKIAMRE is distantly related to the MAP kinase group and closely related to p42 KKIALRE. KKIAMRE is predominantly expressed in testis, kidney, brain, and lung. It contains the conserved MAP kinase dual phosphorylation motif (Thr-Asp-Tyr) and is activated by EGF treatment. Unlike other MAP kinases, EGF-stimulated kinase activity does not require phosphorylation of KKIAMRE and KKIALRE in the Thr-Asp-Tyr motif.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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