Thermo Fisher Scientific CCR2 Monoclonal Antibody (3B6B1)
인간 CCR2 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot, Flow cytometry, ELISA 등 다양한 분석에 적합. 비결합형 형태로 제공되며, 1 mg/mL 농도. 염증 및 면역 반응 연구에 유용한 연구용 시약.
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Thermo Fisher Scientific CCR2 Monoclonal Antibody (3B6B1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B6B1 |
| Immunogen | Purified recombinant fragment of human CD192 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3091052 |
Target Information
CCR2 is a chemokine receptor that regulates monocyte/macrophage trafficking and is upregulated during inflammation. Polymorphisms in CCR2 may be associated with resistance to HIV-1 infection or delayed progression to AIDS. Its ligand, monocyte chemoattractant protein (MCP-1), is produced by endothelial cells, smooth muscle cells, and macrophages, and mediates monocyte infiltration in inflammatory diseases such as atherosclerosis, rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are generated by alternative splicing. CCR2 expression has been reported across various tissues including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessels. Increased CCR2 expression has been observed in CD3+ lymphocytes in rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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