Thermo Fisher Scientific SKI Polyclonal Antibody
Rabbit에서 유래한 SKI 단백질 인식 polyclonal antibody. 비결합형 액상 형태로 제공되며, 0.2 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장. TGF-beta/Smad 신호 조절 연구에 적합. 연구용 전용 제품.
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Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human SKI (amino acids 404–490, UniProt ID: P12755-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2662557 |
Product Specific Information
Immunogen sequence:
SFYSYKSFETA VAPNVALAPP AQQKVVSSPP CAAAVSRAPE PLATCTQPRK RKLTVDTPGA PETLAPVAAP EEDKDSEAEV EVESRE
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 85%
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski also binds to Smad proteins specific to bone morphogenic proteins (BMPs) and blocks BMP signaling in mammalian cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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