Thermo Fisher Scientific SKI Polyclonal Antibody

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human SKI if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SKI,uniProtId:P12755-1,ncbiNodeId:9606,antigenRange:404-490,antigenLength:728,antigenImageFileName:PA5-66852_SKI_P12755-1_Rabbit.svg,antigenImageFileNamePDP:PA5-66852_SKI_P12755-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2662557

Product Specific Information

Immunogen sequence: SFYSYKSFETA VAPNVALAPP AQQKVVSSPP CAAAVSRAPE PLATCTQPRK RKLTVDTPGA PETLAPVAAP EEDKDSEAEV EVESRE

Highest antigen sequence identity to the following orthologs - mouse 85%, rat 85%.

Target Information

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.