Thermo Fisher Scientific TOMM22 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
MAAAVAAAGA GEPQSPDELL PKGDAEKPEE ELEEDDDEEL DETLSERLWG LTEMFPERVR SAAGATFDLS LFVAQKMYRF SRA

Positive Samples: HeLa, HepG2, K-562
Cellular Location: Mitochondrion outer membrane, Single-pass membrane protein

Target Information

Tom22 has a negatively charged N-terminal region exposed to the cytosol, a putative transmembrane region, and a C-terminal intermembrane space region with little negative charge.
The three domains of Tom22 have distinct functions:

• The cytosolic N-terminal domain is important for presequence binding.
• The intermembrane space domain provides a trans binding site for presequences.
• The single membrane anchor is crucial for the integrity of the GIP (general import gene) complex.

The TOM complex of mammalian mitochondria resembles the fungal Tom complex but is distinct from the plant TOM system. While unique components of the mammalian mitochondrial import system have been identified (e.g., TOM34 and metaxin), Tom22 and Tom37 have not been identified in plant mitochondria.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.