Thermo Fisher Scientific ATP Citrate Lyase Polyclonal Antibody
ATP Citrate Lyase 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, Human, Mouse, Rat에 반응. 항원 친화 크로마토그래피로 정제된 1 mg/mL 액상 형태로 제공. 연구용으로만 사용.
- 카탈로그번호
- PA529495
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
- Publications: View 4 publications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
- Publications: View references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 743–1038 of Human ATP Citrate Lyase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546971 |
Product Specific Information
- Recommended positive controls: HeLa, Raji, mouse brain, PC-12, Rat-2
- Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (91%), Pig (98%), Chicken (95%), Sheep (99%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
This enzyme is a tetramer (relative molecular weight approximately 440,000) composed of identical subunits.
It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with ATP hydrolysis to ADP and phosphate.
Acetyl-CoA serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.
In nervous tissue, ATP citrate lyase may be involved in the biosynthesis of acetylcholine.
Two transcript variants encoding distinct isoforms have been identified for this gene.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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