Thermo Fisher Scientific ATP Citrate Lyase Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: View 4 publications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100–1:1,000
• Publications: View references

Product Specifications

Product Specific Information

• Recommended positive controls: HeLa, Raji, mouse brain, PC-12, Rat-2
• Predicted reactivity: Mouse (97%), Rat (97%), Xenopus laevis (91%), Pig (98%), Chicken (95%), Sheep (99%), Bovine (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues.
This enzyme is a tetramer (relative molecular weight approximately 440,000) composed of identical subunits.
It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with ATP hydrolysis to ADP and phosphate.
Acetyl-CoA serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.
In nervous tissue, ATP citrate lyase may be involved in the biosynthesis of acetylcholine.
Two transcript variants encoding distinct isoforms have been identified for this gene.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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