Thermo Fisher Scientific CD72 (B Cell Marker) Monoclonal Antibody (BU40)
CD72 단백질을 인식하는 마우스 단클론 항체로, B 세포 마커 연구에 적합합니다. IHC, ICC, Flow Cytometry, ELISA 등 다양한 응용에 사용 가능합니다. 단백질 A/G 정제, 1 mg/mL 농도의 액상 형태로 제공됩니다. 연구용 전용 제품입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| ELISA | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BU40 |
| Immunogen | HF B1 plasmacytoid cell line |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD72 is a transmembrane glycoprotein expressed as a homodimer, primarily in B cells, but also in other antigen-presenting cells such as dendritic cells and macrophages. Through its immunoreceptor tyrosine-based inhibitory motifs (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72, leading to dissociation of SHP-1 from CD72 and enabling B cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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