Thermo Fisher Scientific GFI1 Monoclonal Antibody (OTI4E2), TrueMAB
GFI1 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot에 적합. 인간 GFI1(aa 1-180) 재조합 단백질을 면역원으로 사용. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–180 of human GFI1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
GFI1 is a nuclear zinc finger (ZF) transcriptional repressor that plays an important role in hematopoiesis and inner ear development, and has been implicated in lymphomagenesis. The GFI1 protein expression is regulated by the ubiquitin-proteasome system. It is reported that ubiquitin ligase Triad1 interacts with the DNA-binding domain of GFI1. GFI1 represses transcription by directly binding to the consensus DNA sequence in the promoters of its target genes. Deficiency of GFI1 causes neutropenia and accumulation of granulomonocytic precursor cells, reminiscent of myelodysplastic syndrome in mice.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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