Thermo Fisher Scientific CRMP5 Polyclonal Antibody
CRMP5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며, IHC(Paraffin)에서 1:500~1:1,000 희석으로 사용 가능. 신경 발달 및 종양 관련 연구에 적합한 고순도 항체로, 항원 친화 크로마토그래피로 정제됨.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human DPYSL5. Recombinant protein control fragment (Product #RP-96158). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2790388 |
Product Specific Information
Immunogen sequence:GRVVYENGVF MCAEGTGKFC PLRSFPDTVY KKLVQREKTL KVRGVDRTPY L
Target Information
The collapsin response mediator protein (CRMP) family (also referred to as ULIP6) are neurologic proteins that play key roles in growth cone guidance during neural development.
CRMP5 shows relatively low sequence homology with other CRMP family members. It is expressed in the developing nervous system with a pattern resembling CRMP2, peaking during the first postnatal week.
Elevated levels of autoantibody to CRMP5 have been linked to paraneoplastic autoimmune optic neuritis and other paraneoplastic neoplasms. Auto-immunity against CRMP5 expression (predominantly the N-terminal epitopes) is being investigated as an oncological marker in the respiratory system and thymus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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