Thermo Fisher Scientific NAB2/MADER Polyclonal Antibody
NAB2/MADER 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ELISA 등 다양한 응용에 적합. 고순도 Protein A 정제, 1 mg/mL 농도, -20°C 보관. 인간, 마우스, 랫트 반응성.
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- BS-11299R
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- pk
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Applications
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:300 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human NAB2, amino acids 221–320 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Transcriptional control is partly regulated by interactions between DNA-bound transcription factors such as Egr-1/NGFI-A and coregulatory proteins like NAB (NGFI-A-binding proteins). The evolutionarily conserved NAB proteins, NAB1 and NAB2, act as corepressors of EGF-1/NGFI-A.
Both NAB1 and NAB2 contain an amino-terminal NAB conserved domain 1 (NCD1) required for NGFI-A binding, and a carboxy-terminal NCD2 domain responsible for repressor function.
NAB2 is primarily localized in the nucleus and may play a role in downregulating NGFI-A activity and controlling cell division, differentiation, and apoptosis.
It has a predicted molecular mass of 56 kDa and localizes to chromosome 12q13.3–14.1, a region rearranged in several solid tumors, lipomas, and liposarcomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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