Thermo Fisher Scientific TAB2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human TAB2 protein. Validated for Western blot and immunoprecipitation. Targets region 500–550 of TAB2. Supplied as liquid, 1 mg/mL, stored at 4 °C. For research use only.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 500 and 550 of Human TAK1-Binding Protein 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4 °C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from the date of receipt.
Target Information
TAB2 is an activator of MAP3K7/TAK1, required for IL‑1–induced activation of NF‑κB and MAPK8/JNK. It forms a kinase complex with TRAF6, MAP3K7, and TAB1, functioning as an adaptor linking MAP3K7 and TRAF6. TAB2, TAB1, and MAP3K7 also participate in TNFSF11/RANKL‑induced signaling via TNFRSF11A/RANK, influencing osteoclast development and function.
Recent studies show TAB2 and TAB3 interact with Beclin‑1, an autophagy mediator. Upon autophagy induction, they dissociate from Beclin‑1 and bind TAK1. Overexpression of TAB2/TAB3 inhibits autophagy, while depletion triggers it, suggesting a regulatory role in autophagy control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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