Thermo Fisher Scientific CTCF Polyclonal Antibody
CTCF 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체입니다. Western blot, ICC/IF, ChIP assay에 적합하며, 고순도 affinity chromatography로 정제되었습니다. 인간 시료에 반응하며, -20°C에서 보관합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:100 |
| ChIP assay (ChIP) | 5 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal of human CTCF (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608662 |
Product Specific Information
Peptide sequence:
MEGDAVEAIV EESETFIKGK ERKTYQRRRE GGQEEDACHL PQNQTDGGEV
Sequence homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Target Information
Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain-containing, DNA-binding nuclear phosphoprotein involved in multiple aspects of gene regulation, including transcriptional repression and activation, gene silencing, chromatin insulation, and imprinting control.
CTCF interacts with the CCCTC motif on DNA and can bind to HAT- and HDAC-containing complexes, influencing transcriptional activation or repression.
It plays roles in transactivation of the APPB gene, silencing of the c-myc gene, insulation of the human beta-globin and DMI myotonic dystrophy loci, and imprinting control of IGF2 and H19 regions.
Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms’ tumors.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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