Thermo Fisher Scientific AFP Recombinant Rabbit Monoclonal Antibody (PD00-71)
Recombinant rabbit monoclonal antibody targeting human AFP for IHC applications. High specificity and sensitivity with 1:200 dilution. Purified via Protein A, supplied in PBS buffer with BSA and glycerol. Ideal for detecting AFP in liver carcinoma and ...
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PD00-71 |
| Immunogen | Recombinant full length protein corresponding to Human alpha 1 Fetoprotein (aa 1–609/609) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 0.1% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3092994 |
Product Specific Information
- Positive Control: Human liver carcinoma tissue, human placenta tissue
- Predicted Band Size: 68 kDa
- Subcellular Location: Secreted
Target Information
Alpha Fetoprotein (AFP) is a major plasma protein produced by the yolk sac, intestinal tract, and liver during fetal life. In adults, AFP expression is often associated with hepatoma or teratoma, though hereditary persistence can occur without pathology. AFP is considered the fetal counterpart of serum albumin, with both genes located tandemly on chromosome 4. It exists in monomeric, dimeric, and trimeric forms and can bind copper, nickel, fatty acids, and bilirubin. AFP levels in amniotic fluid are used to screen for spina bifida and anencephaly. Elevated serum AFP is observed in hepatocellular carcinoma, teratoblastoma, colorectal, pancreatic, and germ cell cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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