Thermo Fisher Scientific OLFM1 Monoclonal Antibody (2G12-1B3)

Applications

Tested Dilution

Publications

ELISA (ELISA)

1 ng/mL

-

Product Specifications

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2G12-1B3

Immunogen

OLFM1 (AAH00189, 1 a.a. approximately 169 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:OLFM1,uniProtId:Q99784-1,ncbiNodeId:9606,antigenRange:1-485,antigenLength:485,antigenImageFileName:H00010439-M01_OLFM1_Q99784-1_House_mouse.svg,antigenImageFileNamePDP:H00010439-M01_OLFM1_Q99784-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MPGRWRWQRD MHPARKLLSL LFLILMGTEL TQNKRENKAE KMGGPESERK TTGEKTLNEL PLFCLEAHAG SLALPRMCSP NPNPAVGLCR PAYPQSPSPG AAQTISQSLL ERFCMASRRE VFLAPGRPGG GWWLCTVAGQ MHSFMCTHTH THAHTGEQIP AEKSQPGPD

Target Information

The Olfactomedin family comprises a diverse group of secreted glycoproteins, which includes OLFM1 (Noelin-1), OLFM2 (Noelin-2), OLFM3 (Noelin-3), OLFM4 (Noelin-4), tiarin, pancortin, gliomedin and mycocilin. These proteins are implicated in the development of the nervous system. Specifically, OLFM1 and OLFM2 expression is observed in the neural plate and neural crest, as well as in the cranial ganglia in mouse at E8-10, and later in brain tissue and in the zone of polarizing activity in the limb. Overexpression of OLFM1 causes an excess of neural crest emigrations and prolonged neural crest production. OLFM2 participates in the regulation of the development of the anterior nervous system. An Arg144Gln mutation in OLFM2 has been implicated as a possible cause for open-angle glaucoma (OAG).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.