Thermo Fisher Scientific MAP3K7IP1 Monoclonal Antibody (2G9)

Thermo Fisher Scientific MAP3K7IP1 Monoclonal Antibody (2G9)

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000
• ELISA: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG AHSASTLDEA TPTLTNQSPT LTLQSTNTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP YVDFAEFYRL WSVDHGEQSV VTAP

Target Information

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) is a regulator of MAP3K7/TAK1, mediating intracellular signaling pathways such as those induced by TGF-beta, interleukin 1, and WNT-1. TAB1 interacts with and activates TAK1 kinase. The C-terminal portion of TAB1 is sufficient for TAK1 binding and activation, while the N-terminal portion acts as a dominant-negative inhibitor of TGF-beta. This protein may function as a mediator between TGF-beta receptors and TAK1 and can also activate MAPK14/p38alpha, providing an alternative activation pathway for MAPK14 responses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.